Hi, I am planning to marry my niece (My Mother's brother's daughter). The confusion that I have is regarding child's birth. Girls mother and father are physically challenged (Deaf and Dump), I would like to get the following clarifications, 1) If I Marry her is there possibility to have child of physically challenged? 2) Is there any possibility to identify the child health at very early stage? 3) Is there any advancement to predict and correct the child problem at mothers womb? Please do suggest on this. Thanks, Deva V.
Its better to have a genetic check before going for a marriage within close relationship with complications.. Best Wishes!
Would'nt MOTHER'S BROTHER'S DAUGHTER BE YOUR SISTER?????? AS IN COUSIN, AND YOU SAID NEICE MAYBE A TYPO ERROR well it is not recommended medically to marry in blood relations........ So talk to a doctor or genelogist or something??? Take care chow
OMG!!!Do u guys marry cousin sisters??? but why? Its not at all advisable from medical point of view....
This practice of marrying cousins unfortunately exists in some states in India. Consult a doctor for genetic evaluation beforehand.
Better consult a specialist before marriage itself. Yes as u asked now there is possibility of checking the genetic problems in the womb itself but I'm not sure about the correcting problem in the womb itself. Anyways have a talk with dr. Wish u good luck
Hi , I am from Andhra Pradesh and its a common practise here where one can marry there cross cousins My parents are cross cousins too..When my brother passed away when he was 5 because of a hole in the heart everyone said its bcause of the genetic issue..But there are cross cousin couples i have seen where they dint have any issues with children..But in your case i would definitely suggest to check with specialist before.Good Luck.
Yes there is. However it is best not to think of it as just physically challenged. There may be other subtle genetic problems that are not easily detected or may show up later in life. Today, in the United States, you can have a person's entire DNA sequenced for abut $5000. However, even if you do that with fetal DNA from your child with your cousin, the chances of finding every possible genetic problem is low. Not all problems can be predicted. None of the complex diseases are understood. Even for the simpler genetic diseases, no treatment or permanent corrective exists. You need to consult a genetic counselor so that both you and your cousin can understand the risks involved. Please ask your physician to refer you to one. What can be offered to couples at (possibl... [J Community Genet. 2012] - PubMed - NCBI "We review the reasons why a couple might seek specialist genetic counselling about a possible reproductive risk and the options available to them. Most commonly, the couple will be concerned about the risk of recurrence of a medical condition that has already occurred in the family. Sometimes, the increased risk may come from their ethnicity or because of a consanguineous marriage, rather than because any problem has occurred previously. The geneticist must identify the exact nature of any problem and determine the risks in the light of the mode of inheritance, any investigations undertaken and any other relevant information. The geneticist will then review the options open to the couple, and help them arrive at their own decision in a non-directive way. Some couples may opt to do nothing and let nature take its course but others may request prenatal or pre-implantation diagnosis, or they may avoid the conception of an at-risk child by using donor gametes, adoption or even decide not to have children." Here are three studies (below) chosen at random. See: Clinical outcomes of consanguineous m... [Turk J Pediatr. 2001 Oct-Dec] - PubMed - NCBI "Turkey has a high rate of consanguineous marriages. Different nationwide surveys indicate that today 20-25% of marriages are consanguineous, with the rate having increased over the last 15 years. The results of many studies show that the rate of consanguinity among parents of children with rare recessive diseases is quite above Turkey's average and that the high consanguinity rate is one of the underlying factors of high infant and child mortality and fertility in Turkey." Reproductive behavior and health in consanguineous marriages "In many regions of Asia and Africa, consanguineous marriages currently account for approximately 20 to 50% of all unions, and preliminary observations indicate that migrants from these areas continue to contract marriages with close relatives when resident in North America and Western Europe. Consanguinity is associated with increased gross fertility, due at least in part to younger maternal age at first livebirth. Morbidity and mortality also may be elevated, resulting in comparable numbers of surviving offspring in consanguineous and nonconsanguineous families. With advances in medicine and public health, genetic disorders will account for an increased proportion of disease worldwide. Predictably, this burden will fall more heavily on countries and communities in which consanguinity is strongly favored, as the result of the expression of deleterious recessive genes. However, studies conducted in such populations indicate that the adverse effects associated with inbreeding are experienced by a minority of families." Consanguinity, fertility, reproductive wastage, ... [Saudi Med J. 2000] - PubMed - NCBI "The study showed that fertility, as measured by the number of pregnancies, taking into consideration marriage duration, was not affected by consanguinity. Twin pregnancies and abortions did not show any significant difference between consanguineous and non-consanguineous marriages. Consanguineous marriages showed significantly higher rates of still births and infant mortality in general. Within the consanguineous group, female infant mortality rates were significantly higher than those of males. Congenital malformations as reported by mothers of consanguineous marriages were significantly higher than those reported by mothers of non-consanguineous marriages."