I don't know about low birth weight, but my child was normal birth weight. But I can share my experience. My child has been on diapers since day 1, like Pampers, Huggies etc and never had any issues. But the secret is to apply diaper rash cream diligently in every diaper change. More during summer months. Be it just urine diaper, or potty diaper, I have been applying diaper cream generously in the diaper area, this keep friction and sweat away and keeps them happy and fine. Hope this helps.